The PlayStation Portable version of Spider-Man 2 uses the same engine as 2002’s Spider-Man. Because of this, the gameplay is virtually unchanged, and many locations from the first game are reused, as is its scoring system, which assigns players a score at the end of each level based on various factors, such as the time taken to complete the level and the number of combos used. The player can crawl walls and web swing, though Spider-Man is only able to move forward in a straight line. They can also lock their camera onto certain enemies and web them.

As Spider-Man, players must master new combo moves as they protect the city of Manhattan from the nefarious Doc Ock and other classic Marvel villains by swinging, jumping and wall-crawling through 19 new levels that extend beyond the film. Featuring an unprecedented depth of gameplay, players experience original storylines and battle through graphically rich 3D environments. Swing, climb and web-sling through interactive 3D environments while experiencing scenarios, settings and characters based on the hit film and others that are exclusive to the game. In addition to Doc Ock, gamers must battle a plethora of characters in Spider-Man’s legendary Rogue’s Gallery of villains, such as Mysterio, Rhino, Shocker and Vulture. Utilizing the graphical power of the PSP, Spider-Man 2 delivers amazing console-like 3D graphics and incredibly immersive gameplay never before seen in a handheld Spider-Man game. Beyond Spider-Man’s signature set of moves which include wall crawling, web yanking and capture webbing, Spider-Man 2 PSP brings a host of new moves to the handheld such as the “cocoon,” “web net” and “heavy web ball.”